When Sciences meet Arts...
Our "Synaptic Constellation" picture is awarded at the Science & Art photo contest from Neuroschool Marseille 🎉🎉
Confocal microscopy showing reconstructed synapses in a brain-on-a-chip device. Brain on a chip systems allow to reconstruct neuronal networks in a near-physiological environment using microfluidic compartmentalization of primary neuronal cultures. Here, synaptophysin (presynaptic marker, magenta) juxtaposes to PSD95 (postsynaptic marker, cyan) in an isolated microfluidic chambers enriched in synapses.
Enjoying Thai food at l'Indécis before we all leave the lab for a well deserved summer break !
Aloha ! 🏖🏝⛱🏄♂️
It is our great pleasure to welcome Christoph Kellendonk from Columbia Univ, NY. Christoph will present his latest results on the role of thalamo-cortical projections in cognition and in schizophrenia.
Always nice to chat about science and life with you!
Killing two birds with one stone: having lunch with the NeuroTech Center and surprising Rod with an impromptu BDay celebration !
Happy Birthday Rod 🎉🎉
Despite appearances, this is not a Masquerade Ball, but SONIC team's first Xmas party! (COVID-approved)
From Left to right: Max, Cynthia, Natalia, Eduardo, Elodie, Ana, Catherine, and Florence
We are happy to announce our fusion with Eduardo Gascon's team at the INT!
Eduardo's team mirCOS investigates the neural bases of social cognition using a network-based transcriptomic approach in mice and monkeys.
The fusion will lead to the creation of a new team entitled Social cogNItion and Connectomics (SoniC) where we will study and manipulate the neural circuits controlling social behaviors.
The synergy of the new team will allow to develop a multidisciplinary approach, using transcriptomics analyses, live cell imaging, virus-based connectomics, optogenetics, and behavioral phenotyping in mice and marmosets.
After 5 years in Grenoble, we are officially moving to Marseille! Many thanks to all my collaborators at the GIN for the good moments and great work!
Excited for the future, and to move to the Neurotech Center of La Timone Medical campus. Welcoming postdocs, techs, and students to study how adult brain circuits rewire during learning or when confronted to environmental changes.
Goodbye snowy mountains, hello turquoise sea !
After many twists and turns during this hectic COVID-19 period, Eve finally defends her thesis (though remotely) entitled “Régulation du transport axonal par l’activité neuronale : Implication pour le développement des réseaux neuronaux” Committee: Dr. Zsolt Lenkei (Paris), Dr. Xavier Nicol (Paris Univ), Dr. Christophe Leterrier (Aix-Marseille Univ), Dr. Annie Andrieux (President, Grenoble Alpes Univ), Pr. Frederic Saudou (Grenoble Alpes Univ), Dr. Maxim Cazorla (Grenoble Alpes Univ/Aix-Marseille Univ).
Our project on the molecular mechanisms of neural network remodeling in the adult brain (SARABANDE project) is awarded a National Agency Research Young Investigator grant (ANR-JCJC)
Eve’s paper in Lab Chip is out!! “An integrated microfluidic/microelectrode array for the study of activity-dependent intracellular dynamics in neuronal networks” by Moutaux E, Charlot B, Genoux A, Saudou F, and Cazorla M
Julien defends his Master at Grenoble INP Phelma. Congrats !
Eve’s paper in Scientific Reports is out!! “Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons” by Moutaux E, Christaller, W, Scaramuzzino C, Genoux A, Charlot B, Cazorla M*, and Saudou F*
Julie Anne defends her thesis entitled “Identification d’une forme phosphorylée de BDNF: un nouveau mécanisme de régulation de la plasticité synaptique et de la mémoire ?” Committee: Dr. Helene Marie (Nice Univ), Pr. Yves-Alain Barde (Cardiff Univ), Dr. Servane Tauszig-Delamasure (Lyon Univ), Dr. Peter Vanhoutte (Paris-Sorbonne Univ), Pr. Remy Sadoul (President, Grenoble Alpes Univ), Pr. Frederic Saudou (Grenoble Alpes Univ), Dr. Maxim Cazorla (Grenoble Alpes Univ)
We are extremely pleased to welcome Prof Yves-Alain Barde from Cardiff University. Yves Alain will present his work on “Neurotrophins in development and diseases of the nervous system” before Julie Anne’s thesis defense
Rachel defends her Master thesis at Grenoble Alpes University. Congrats !
Public media talk about our work ! Check out Le Monde (La maladie de Huntington mise en microtubes), 20 Minutes (Maladie de Huntington: Des chercheurs ont recréé le trouble cérébral sur une puce électronique), Sciences & Avenir (Une puce va permettre de mieux comprendre la maladie de Huntington) and Pour La Science (La microfluidique éclaire la maladie de Huntington).
Amandine’s paper is out in Cell Reports!! “Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease” by Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F
Max is presenting our work on “Brain-on-a-chip reconstruction of corticostriatal networks to study Huntington’s disease” at the CoEN Annual meeting (Centre d’Excellence sur les maladies Neurodégénératives) in Montpellier
Clementine defends her Master at Grenoble INP Phelma. Congrats !
We are at the 2017 NeuroFrance Meeting in Bordeaux
Our ATK program for the development of positive allosteric modulators of TrkB is selected by SATT Conectus Alsace for a 3 year Development of Innovative Projects program !
Theo defends his Master at Grenoble INP Phelma. Congrats !
Our collaborators Michel Verheij and Candice Contet from The Scripps Institute release their paper in J Neuroscience: “Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex“. Congratulations !
Ready to start a SATT Conectus Alsace Prematuration Program with our collaborator Didier Rognan (LIT, Strasbourg) ! The aim of the project is to establish the proof of concept for the development of positive allosteric modulators of TrkB
Eve defends her Master at Grenoble INP Phelma. Congrats !
Dr Pierre Trifilieff (Bordeaux Neurocampus) visits us at the GIN and presents his work on “Dopamine D2 receptor signaling in reward processing: From heteromerization to modulation by membrane lipids” (and enjoys a good weekend of fresh powder!)
Mariya defends her Master at Grenoble Alpes University. Congrats !
Our collaborator Benoit Charlot (IES, Montpellier) visits us and presents his work entitled “Micro and nanotechnologies for life sciences : single molecule combing, microfluidics for neurosciences and infrared stimulation of action potential in neurons”
Joining the Grenoble Institute of Neuroscience in F. Saudou's Team "Intracellular Dynamics and Neurodegeneration" to study how neuronal activity controls axon remodeling in mature circuits. Specifically, we will explore how vesicular trafficking responds to electrical signals to address essential materials to active axonal branches, using high-resolution fast videomicroscopy in brain-on-a-chip devices.